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13.01.2012 38 " 27 2005 . 549"

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                                                                                         (                                     
                                                                                        ),                                     
                                                                                        1- ,                                        
                                                                                         -  5- ;                                       
                                                                                        - 5 / ,                                          
                                                                                       11-    .                                         
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..          HR I                          HR I            20 ,                     
.                                                HR I                                                                   
 .                                                                                                       14-                    
 HR IV                                                                                                                                                
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..          HR I                          HR II           20 ,                     
.                                                HR I                                                                   
 .                                                                                                       14-                    
 HR V                                                                                                                                                 
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..          HR I                          HR III          20 ,                     
.                                                HR I                                                                   
 .                                                                                                       14-                    
                                                                                                                                       
.                                                                                                                                             
 .                                                                                                                                           
 HR VI                                                                                                                                                
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..                 1- :                      1 - 29                          
.                                      - 10 /.,                                         
 .                     ,             C-   1-  29- ,                                       
 II                          ,  .                       ;                                     
                                    .                              - 1,5 /. (.                                    
                                               .              2 ), ,  8, 15,                                      
                                                     22, 29- ;                                                      
                                                .               - 25 /.,                                         
                                     ,         ,  8, 15, 22, 29-                                    
                                     ,      .           ;                                                               
                                    , ,             L- (Medac) - 10000                                     
                                    , ,  ,      /.,   1 ,                                     
                                    K, Na, Mg, Ca, Cl, P,  .                     8, 12, 15  18- ;                                           
                                                                                        
                                    , , , .    -          (                                      
                                                     ),                                                
                                    .                                                                                                           
                                    .                                               2- :                      36 - 49                         
                                                                6- - 60 /.,                                          
                                    :                              ,  36-  49- ;                                      
                                    , , ,                             - 1000 /.,                                      
                                    .                                                ,  36- ;                                         
                                                                     - 400 /.,                                         
                                    .                                              ,   0, 4                                      
                                    .                                               8-                                                    
                                                                              ;                                                    
                                                                                        - 75 /.,                                            
                                                                                       , ,                                            
                                                                                       38 - 41  45 - 48- .                                           
                                                                                                                                    
                                                                                        (                                      
                                                                                       ),   38                                        
                                                                                       45-                                                            
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
       ..,                        2                     
    ˦..                                                  
                                 .                                       
:                                                                                     
--                       .                                                                          
,                                                                                                                             
                                                                                                                         
                         6, 12  24                                                                                                
100000 /                                                                                                                      
,                    ( -                                                                                                    
36-                    )                                                                                                           
,                                                                                                                                               
                                                                                                                                       
36-                                                                                                                                                  
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
,    ..                         ALL-BFM 2000 +8 - 9                        
  t(4;11)                             :                                           
                                                                                  , 6                                            
                                                                                       HR-,  II,                                     
                                                                                       ,                                             
                                                                                       ,                                               
                                                                                                                                    
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..                           36                              
                                                                                       
                                                                                 --2008                                                        
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR I   ..          HR-     HR I ALL-BFM 2000:        20 ,                     
ALL-BFM 2000                         ALL-BFM 2000:           - 20 /.,                        
                                            C-   1-  5- ;     14-                    
                                         .                      - 1,5 /. (.                                    
                                    ,                     2 ), ,  1  6-                                      
                                     ,  .              ;                                                               
                                    .                                - 5000 /.,                                     
                                               .                24-   1-                                    
                                                 (1/10    1/2                                    
                                                 .           ,  9/10 -  23                                       
                                     ,             1/2 );                                                         
                                     ,     ,  ,        - 15 /.,                                      
                                    , ,   .                    ,  42, 48  54-                                      
                                    ,                                                    
                                    K, Na, Mg, Ca, Cl, P,  -         ;                                                      
                                                    - 200 /.,                                       
                                    , , , .                                 1 , 5                                            
                                                                       12                                         
                                    .                                        ,  2, 3  4- ;                                          
                                    .                                                - 70 /.,                                          
                                                                   0, 4                                       
                                    :                              8-                                                    
                                    , , ,                            ;                                                    
                                    .                                                 - 150 /.,                                          
                                                                    ,                                           
                                    .                                                ;                                        
                                                                       - 2000 /.,                                          
                                                                    3-                                       
                                    .                                                12 ,                                     
                                    .                                                5-  ( 2 );                                    
                                     .                                        L- (Medac) - 25000                                     
                                     pH                                  /.,   2                                      
                                                                              6- ;                                                       
                                                                                       //                                         
                                                                                         (                                     
                                                                                        ),                                     
                                                                                        1- ,                                        
                                                                                         -  5- .                                       
                                                                                                                                
                                                                                        - 25 /., ,                                     
                                                                                       7-  20- .                                                 
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR II  ..          HR I                    HR II ALL-BFM 2000:       20 ,                     
ALL-BFM 2000                        ALL-BFM 2000            HR I ALL-BFM 2000           - 20 /.,                        
                                                                                         ,  1- 14-                    
                                                                                        5- ;                                                       
                                                                                        - 3 /. (.                                        
                                                                                       5 ),  ,                                       
                                                                                       1  6- ;                                                       
                                                                                        - 5000 /.,                                     
                                                                                         24-   1-                                    
                                                                                        (1/10    1/2                                    
                                                                                       ,  9/10 -  23                                       
                                                                                       1/2 );                                                         
                                                                                         - 15 /.,                                      
                                                                                       ,  42, 48  54-                                      
                                                                                                                                      
                                                                                       ;                                                      
                                                                                        - 800 /.,                                           
                                                                                       ,  2, 3, 4- ;                                     
                                                                                        - 300 /.,                                         
                                                                                       ,  0, 4  8-                                         
                                                                                          ;                                         
                                                                                        - 30 /.,                                         
                                                                                       , 24-                                            
                                                                                       ,  5- ;                                              
                                                                                       L- (Medac) -                                           
                                                                                       25000 /.,   2                                    
                                                                                         6- ;                                                  
                                                                                       //                                         
                                                                                         (                                     
                                                                                        ),                                     
                                                                                        1- ,                                        
                                                                                         -  5- .                                       
                                                                                                                                
                                                                                        - 25 /., ,                                     
                                                                                       7-  20- .                                                 
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR III ..          HR I                    HR III ALL-BFM 2000:      20 ,                     
ALL-BFM 2000                        ALL-BFM 2000            HR I ALL-BFM 2000           - 20 /.,                        
                                                                                         ,  1- 14-                    
                                                                                        5- ;                                                       
                                                                                        - 150 /.,                                          
                                                                                       ,                                           
                                                                                         ;                                        
                                                                                        - 2000 /.,                                          
                                                                                        3-                                       
                                                                                         12 , 1  2-                                     
                                                                                        ( 4 );                                            
                                                                                        - 100 /.,                                            
                                                                                       ,  5                                      
                                                                                        12 ,                                        
                                                                                       3- ;                                                          
                                                                                       L- - 25000 /.,                                    
                                                                                         2 ,  6-                                      
                                                                                       ;                                                              
                                                                                       //                                         
                                                                                         (                                     
                                                                                        ),                                     
                                                                                        1- ,                                        
                                                                                          5- .                                         
                                                                                                                                
                                                                                        25 /., ,                                       
                                                                                       7-  20- .                                                 
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR IV  ..          HR I                     HR I ALL-BFM    20 ,                     
ALL-BFM 2000                         ALL-BFM 2000  HR I ALL-BFM 2000          2000:                                  
                                                                                       L-  11-    14-                    
                                                                                       .                                                               
                                                                                                                                
                                                                                        25 /., ,                                       
                                                                                       7-  20-                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR V   ..          HR I                     HR II ALL-BFM   20 ,                     
ALL-BFM 2000                        ALL-BFM 2000            HR I ALL-BFM 2000          2000:                                  
                                                                                       L- 11-     14-                    
                                                                                       .                                                               
                                                                                                                                
                                                                                        25 /., ,                                       
                                                                                       7-  20-                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR VI  ..          HR I                     HR III ALL-BFM  20 ,                     
ALL-BFM 2000                        ALL-BFM 2000            HR I ALL-BFM 2000          2000:                                  
                                                                                       L-  11-    14-                    
                                                                                       .                                                               
                                                                                                                                
                                                                                        25 /., ,                                       
                                                                                       7-  20-                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 II          ..                 1-               1 - 33                           
                                                  ALL-BFM 2000:                                                      
                                    ,             -  - 10 /.,                                         
                                     ,  .                       1-  29- ,                                       
                                    .                                                                    
                                               .              32- ;                                                         
                                                      - 1,5 /. (.                                    
                                                .              2 ), ,  8, 15,                                      
                                     ,         22, 29- ;                                                      
                                     ,      .            - 30 /.,                                         
                                    , ,             ,  8, 15, 22, 29-                                    
                                    , ,  ,      ;                                                               
                                    K, Na, Mg, Ca, Cl, P,  .                    L- (Medac) -                                           
                                           10000 /.,   1                                    
                                    , , , .    -         ,  8, 11, 15  18- ;                                      
                                                                                                  
                                    .                                         (                                      
                                    .                                               ),                                          
                                                                 , , 1                                    
                                    :                               18 .                                                          
                                    , , ,                                                                        
                                    .                                                                                                                   
                                                                    2-               36 - 49                         
                                    .                                              ALL-BFM 2000:                                                      
                                    .                                               6- - 60 /.,                                          
                                                                              ,  36-  49- ;                                      
                                                                                        - 1000 /.,                                      
                                                                                       ,  36- ;                                         
                                                                                        - 400 /.,                                         
                                                                                       ,   0, 4                                      
                                                                                       8-                                                    
                                                                                       ;                                                    
                                                                                        - 75 /.,                                            
                                                                                       , ,  38 -                                      
                                                                                       41  45 - 48- ;                                                
                                                                                                                                    
                                                                                        (                                      
                                                                                       ),   38                                        
                                                                                       45- .                                                          
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
       ..,                    2                     
              ..         --2008.     --2008        --2008,                                      
                                                                                                                       
                                                                                                                    
                                                                                       25 /.   14 ,                                      
                                                                                                                                                    
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..                         EsPhALL:      8 - 9                        
t(9;22)                                     ,                                      
                                                                                 I2, 3                                             
                                                                                       ,                                                   
                                                                                                                               
                                                                                       ( )                                             
                                                                                        II,  ,                                      
                                                                                        II,                                         
                                                                                                                              
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..,                             36                              
        ..               --2008                                                        
t(9;22)                                                                                                                                             
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 I2       ..                  I2:                   29                              
  t(9;22)                               6- - 60 /.,                                      
                                    ,             C- ,  36-  64- ;                                      
                                     ,  .                      - 300 /., ,                                    
                                    .                              36-  64- ;                                              
                                               .               - 1000 /.,                                      
                                                     ,  36  64- ;                                     
                                                .               - 400 /.,                                         
                                     ,         ,  0, 4  8-                                     
                                     ,      .             ;                                          
                                    , ,              - 75 /.,                                            
                                    , ,  ,      ,   38 -                                       
                                    K, Na, Mg, Ca, Cl, P,  .                    41, 45 - 48, 52 - 55, 59 - 62-                                    
                                           ;                                                               
                                    , , , .    -                                                      
                                                      (                                      
                                    .                                        ),   38                                        
                                    .                                               45- .                                                          
                                                                                                            
                                    :                                                                                                 
                                    , , ,                                                                                               
                                    .                                                                                                                   
                                                                                                                                       
                                    .                                                                                                                 
                                                                                                                                         
                                                                                                                                    
                                    .                                                                                                                
                                    .                                                                                                                  
                                                                                                                                                 
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR I         ..          HR I       HR I          HR I   20 ,                     
  t(9;22)                  ALL-BFM 2000   ALL-BFM 2000     ALL-BFM 2000:                          
                                                                                       L-  11- .   14-                    
                                                                                                                                       
                                                                                       300 /.  7-  20-                                         
                                                                                       ,                                                        
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR II        ..          I          II   HR II  20 ,                     
  t(9;22)                  ALL-BFM 2000  ALL-BFM 2000               ALL-BFM 2000:                          
                                                                                       L-  11- .   14-                    
                                                                                                                                       
                                                                                       300 /.  7-  20-                                         
                                                                                       ,                                                        
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR III       ..          I          I    HR III 20 ,                     
  t(9;22)                  ALL-BFM 2000  ALL-BFM 2000               ALL-BFM 2000:                          
                                                                                       L-  11- .   14-                    
                                                                                                                                       
                                                                                       300 /.  7-  20-                                         
                                                                                       ,                                                        
                                                                                                                                                          
                                                                                                                                       
                                                                                                                                      
                                                                                                                               
                                                                                       ( - ).                                                     
                                                                                                                               
                                                                                       .                                                         
                                                                                       ,   -                                    
                                                                                                                               
                                                                                       ,                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 II (..                 1- :                      1 - 29                          
II                                 - 10 /.,                                         
 )                 ,             C-   1-  29-                                          
  t(9;22)                  ,  .                     (  1   10                                       
                                    .                               1 );                                           
                                               .              1- :                                                          
                                                      - 10 /.,                                         
                                                .                1-  8- ,                                         
                                     ,          15-  22-  (                                      
                                     ,      .            10 );                                                    
                                    , ,              - 1,5 /. (.                                    
                                    , ,  ,      2 ), ,  8, 15,                                      
                                    K, Na, Mg, Ca, Cl, P,  .                    22, 29- ;                                                      
                                            - 25 /.,                                         
                                    , , , .    -         ,  8, 15, 22, 29-                                    
                                                     ;                                                               
                                    .                                        L- - 10000 /.,                                    
                                    .                                                 1 ,  8, 12,                                    
                                                                15  18- ;                                                     
                                    :                                                                           
                                    , , ,                             (                                      
                                    .                                                ),   38                                        
                                                                    45- .                                                          
                                    .                                                                                          
                                                                                                                                         
                                                                 2- :  2-     36 - 63                         
                                    .                                              II ALL-BFM 2000.                                         
                                    .                                                                                               
                                                                              300 /., ,                                          
                                                                                       36-  63-                                                   
                                                                                                                                                          
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
        ..                 6- -              1 - 29                          
                                    50 /., ,  1-                                       
                 ,             C- 29- ;                                                         
 t(9;22)                            ,  .                      - 20 /.,                                          
                                    .                             , 8, 15, 22, 29- .                                       
                                               .                                                           
                                                      (                                      
                                                .              ),   15,                                        
                                     ,         22-                                                            
                                     ,      .                                                                              
                                    , ,                                                                                
                                    , ,  ,                                                                         
                                    K, Na, Mg, Ca, Cl, P,  .                                                                                       
                                                                                                              
                                    , , , .    -                                                                            
                                                                                                                             
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
    ..                -        ,   2 ,  10 - 14                         
  t(9;22)                                                                                 
                                    ,                                       12 ;  2  -                                          
                                     ,                             18 .                                                             
                                    .                                                   -                                     
                                                                          24                                                               
                                                                                                                                        
                                                                                                                                              
                                     ,                                                                                                 
                                     ,                                                                                                   
                                    , ,                                                                                                 
                                    ,                                                                                               
                                    K, Na, Mg, Ca, Cl, P,                                                                                                
                                                                                                                                    
                                    , , , .                                                                                                  
                                                                                                                                           
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 II          ..                           63                               
()                          II                II                                                       
  t(9;22)                 II                                                                                                                    
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
       ..,                  :         2                     
  ..                           6- - 50 /.,                               
 t(9;22)                           --2008.            --2008                ,                                              
                                                                      ;                                                           
                                    -                                        - 30 /.,                                          
                                                                   1   .                                      
                                                                                6-                                             
                                                                                                                               
                                                                                                                                       
                                                                                       .                                                        
                                                                                                                                  
                                                                                             9                                                            
                                                                                       3 x 10 /  6-                                    
                                                                                                                               
                                                                                       1,5 .                                       
                                                                                                   9                                                      
                                                                                        2 x 10 /                                            
                                                                                          2                                         
                                                                                       .                                           
                                                                                                      9                                                   
                                                                                        1,0 x 10 / -                                               
                                                                                                                                    
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..                         MLL-Baby 2006. 2     5-  
    1                          :                
,                                                               1)                                  59%             
                                                                              1 .                                        
(                                                                      ;                                                  
                                                                             2)                                           
                                                                                                              
)                                                                                   :                                                             
                                                                                            6  - 2/3                                     
                                                                                            ;                                              
                                                                                             6                                         
                                                                                          ,   12                                            
                                                                                           - 3/4                                        
                                                                                          ;                                                           
                                                                                             12                                      
                                                                                           -                                                  
                                                                                                                                       
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
  ..                    36                              
                                                   .                                              
                                    ,             C-                                         
                                     ,  .                     3 /.                                             
                                    .                             :  1                                           
                                               .               80  4%                                               
                                                      .                                                
                                                .              :                                                         
                                     ,          - 6 /.,                                          
                                     ,      .           , 1 - 29- ,                                             
                                    , ,                38-                                      
                                    , ,  ,      ;                                                               
                                    k, Na, Mg, Ca, Cl, P,  .                      -                                          
                                           25 /.,  36 - 43-                                       
                                    , , , .    -         ;                                                               
                                      .                    - 45 /.,                                         
                                    +                                                  , 8  22- ;                                         
                                     pH                                    - 1,5 /. (.                                    
                                                                           2 ), ,                                       
                                                                                       8, 15, 22, 29, 36- ;                                           
                                                                                       //                                          
                                                                                         ,                                    
                                                                                       , 0 (1), 8, 15,                                       
                                                                                       22, 29, 36- .                                                  
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
      ..                       :       170                             
 (  1                           1   6- - 50 /.                                       
)                               ,              (                                               
                                     ,                                                                  
                                    .                                                  ),                                       
                                                                          , 43 - 84, 99 - 140,                                         
                                                                     155 - 196- ;                                                   
                                                                            - 30 /.,                                          
                                     ,                               1   ,                                      
                                     ,                                43, 50, 57, 64, 71, 78, 99,                                        
                                    , ,                              106, 113, 120, 127, 134, 155,                                      
                                    ,                            162, 169, 176, 183, 190- ;                                     
                                    K, Na, Mg, Ca, Cl, P,                             L- - 10000 /.,                                    
                                                                  1   ,                                      
                                    , , , .                               44, 51, 58, 65, 72, 79, 100,                                       
                                      .                                 107, 114, 121, 128, 135, 156,                                      
                                                                    163, 170, 177, 184, 191- ;                                     
                                    .                                               - 30 /.,                                         
                                                                                                        
                                    :                              6 ,  43, 64, 85, 106                                       
                                    , , ,                            127- ;                                                         
                                    .                                                 - 6 /.,                                          
                                     .                                           10                                       
                                    .                                                                                       
                                                                      3 , 85 - 98, 141 - 154,                                         
                                                                                197 - 210- ;                                                   
                                                                                         -                                          
                                                                                       25 /., , 85 - 98,                                       
                                                                                       141 - 154, 197 - 210- ;                                        
                                                                                        - 1,5 /. (.                                    
                                                                                       2 ),  , 85,                                    
                                                                                       92, 141, 148, 197, 204- .                                      
                                                                                       //                                         
                                                                                         (                                      
                                                                                       ), , 43, 57,                                      
                                                                                       71, 85, 141, 197- .                                            
                                                                                                                                   
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
,   1 , ..                    MLL-Baby 2006                                     
                  MLL-Baby 2006   MLL-Baby 2006                                                                                 
(t(4;11)                                                                                                                                         
  36-                                                                                                                                          
)                                                                                                                                                     
+---------------------+---------------+------------------------+---------------------------+-------------------------------+--------------------+----------------+
 HR I   ..                  HR I:                     20 ,                     
MLL-Baby 2006                                      - 20 /.,                        
                                    ,             C- ,  1-  5- ;    14-                    
                                     ,  .                     6- - 100 /.,                                     
                                    .                             ,  1-  5- ;                                        
                                               .               - 1,5 /. (.                                    
                                                     2 ), , 1  6-                                        
                                                .              ;                                                               
                                     ,          - 2000 /.,                                        
                                     ,      .              24-                                      
                                    , ,              (1/10                                        
                                    , ,  ,      1/2 , 9/10  -  23                                       
                                    K, Na, Mg, Ca, Cl, P,  .                    1/2 ), 1- ;                                               
                                             - 15 /.,                                      
                                    , , , .    -         , ,  42,                                       
                                                     48  54-                                              
                                    .                                         ;                                             
                                    .                                                - 150 /.,                                          
                                                                ,                                           
                                    :                                ;                                        
                                    , , ,                             - 2000 /.,                                          
                                    .                                                 3-                                       

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